晋小婷 教授

　　晋小婷，青岛大学特聘教授，博士生导师，山东省泰山青年学者，山西省三晋英才青年优秀人才；担任学院青年教师联合会主任，以及劳动卫生与环境卫生学系副主任，主持学系工作。

　　长期致力于研究环境污染物的心血管风险及毒性机制，旨在揭示环境因素在心血管疾病发生发展中的作用，目前已在环境毒理学领域重要杂志发表论文50余篇，第一及通讯作者SCI论文27篇，含影响因子大于10的高水平期刊论文10篇，代表性论文荣获山西省第十九届优秀论文一等奖和二等奖。主持国家及省级科研项目6项，包括国家自然科学基金面上项目、国家自然科学基金重点项目子课题、国家自然科学基金青年项目、中国博士后科学基金等项目。

　　兼任《环境与职业医学》杂志青年编委、生化与分子毒理学专业委员会委员、山东省青年科学家协会会员、中国医疗保健国际交流促进会公共卫生与预防医学分会委员、北京环境诱变剂学会青年专业委员会委员等；担任Journal of Hazardous Materials、Science of The Total Environment、Ecotoxicology and Environmental Safety、Aquatic Toxicology等国内外知名环境毒理学期刊的审稿人。

　　作为研究生指导教师，共指导博士和硕士研究生18名，已毕业硕士研究生6名。培养的硕士研究生共荣获六次研究生国家奖学金、优秀毕业生称号、省优秀研究生成果二等奖等荣誉。指导本科生“大学生创新创业大赛计划项目”入选国家级。

一、主要研究方向

关键词：心血管、造血免疫、数据分析

1. 环境浓度颗粒物暴露诱发心血管风险的毒性机理研究

2. 环境浓度颗粒物暴露对机体造血免疫功能的扰动研究

3. 基于单细胞水平的生物信息学数据分析方法解析污染物的心肺健康风险

二、近5年内代表性科研成果（第一及通讯作者）

1. Xiaoting Jin#, Jingxu Zhang#, Yanting Li, Ze Zhang, Tenglong Cui, Yuanyuan Wang, Linlin Yao, Xiaoxi Yang, Guangbo Qu*, Yuxin Zheng, Guibin Jiang. Exogenous Chemical Exposure Increased Transcription Levels of Host Virus Receptor Involving Coronavirus Infection, Environmental Science & Technology. 2022, 56(3):1854-1863.

2. Haiyi Yu#, Liting Xu#, Tenglong Cui, Yu Wang, Baoqiang Wang, Ze Zhang, Ruijun Su, Jingxu Zhang, Rong Zhang, Yanhong Wei, Daochuan Li, Xiaoting Jin*, Wen Chen, Yuxin Zheng. The foam cell formation associated with imbalanced cholesterol homeostasis due to airborne magnetite nanoparticles exposure. Toxicological Sciences. 2022; kfac079. doi: 10.1093/toxsci/kfac079.

3. Ze Zhang#, Liu Wu#, Tenglong Cui, Rifat Zubair Ahmed, Haiyi Yu, Rong Zhang, Yanhong Wei, Daochuan Li, Yuxin Zheng, Wen Chen, Xiaoting Jin*. Oxygen sensors mediated HIF-1α accumulation and translocation: A pivotal mechanism of fine particles-exacerbated myocardial hypoxia injury. Environmental Pollution 300 (2022) 118937.

4. Ruijun Su#, Xiaoting Jin#, Wenjing Zhao, Xiaoying Wu, Feihong Zhai, Zhuoyu Li*. Rutin ameliorates the promotion effect of fine particulate matter on vascular calcification in calcifying vascular cells and ApoE -/- mice. Ecotoxicology and Environmental Safety. 2022; 234:113410.

5. Xiaoting Jin, Haiyi Yu, Ze Zhang, Tenglong Cui, Qi Wu, Xiaolei Liu, Jie Gao, Xingchen Zhao, Jianbo Shi, Guangbo Qu, Guibin Jiang. Surface charge-dependent mitochondrial response to similar intracellular nanoparticle contents at sublethal dosages. Particle and Fibre Toxicology. 2021 Sep 26;18(1):36.

6. Xiaoting Jin, Huilan Su, Liting Xu, Yu Wang, Ruijun Su, Ze Zhang, Ge Guan, Zhuoyu Li*. Different co-culture models reveal the pivotal role of TBBPA-promoted M2 macrophage polarization in the deterioration of endometrial cancer. Journal of Hazardous Materials. 2021, 400.

7. Xiaoting Jin, Honyan Yu, Baoqiang Wang, Zhendong Sun, Ze Zhang, Qian S. Liu, Yuxin Zheng, Qunfang Zhou*, Guibin Jiang. Airborne particulate matters induce thrombopoiesis from megakaryocytes through regulating mitochondrial oxidative phosphorylation. Particle and Fibre Toxicology. 2021, 18:19.

8. Ge Guan, Huilan Su, Xiaoran Wei, Yuxin Zheng, Xiaoting Jin*. The promotion of tetrabromobisphenol A exposure on Ishikawa cells proliferation and pivotal role of ubiquitin-mediated IκB′ degradation. Ecotoxicology and Environmental Safety. 2021, 207, 111254.

9. Huilan Su, Ge Guan, Rifat Zubair Ahmed, Liang Lyu, Zhuoyu Li, Xiaoting Jin*. TBBPA stimulated cell migration of endometrial cancer via the contribution of NOX-generated ROS in lieu of energy metabolism. Journal of Hazardous Materials 400 (2020) 123204.

10. Jingxu Zhang, Qunfang Zhou, Ruijun Su, Zhendong Sun, Weifang Zhang, Xiaoting Jin*, Yuxin Zheng. Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure. Science of the Total Environment 721 (2020) 137792.

11. Ze Zhang, Huilan Su, Rifat Zubair Ahmed, Yuxin Zheng, Xiaoting Jin*. Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism. Environmental Pollution 264 (2020) 114659.

12. Xiaoting Jin, Qianchi Ma, Zhendong Sun, Xuezhi Yang, Qunfang Zhou*, Guangbo Qu, Qian Liu, Chunyang Liao, Zhuoyu Li, Guibin Jiang. Airborne fine particles induce hematological effects through regulating the crosstalk of the kallikrein-kinin, complement and coagulation systems. Environmental Science & Technology. 2019, 53 (5), 2840-51.

13. Xiaoting Jin, Bin Xue, Rifat Zubair Ahmed, Guobin Ding, Zhuoyu Li*. Fine particles cause the abnormality of cardiac ATP levels via PPARɑ-mediated utilization of fatty acid and glucose using in vivo and in vitro models. Environmental Pollution. 2019, 249, 286-94.

14. Xiaoting Jin, Huilan Su, Guobin Ding, Zhendong Sun, Zhuoyu Li*. Exposure to ambient fine particles causes abnormal energy metabolism and ATP decrease in lung tissues. Chemosphere. 2019, 224, 29-38.

15. Xiaoting Jin, Ruijun Su, Ruijin Li, Li Song, Meilan Chen, Long Cheng, Zhuoyu Li*.Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells. Chemosphere. 2016, 144, 459-66.

16. Xiaoting Jin, Li Song, Zhuoyu Li*, Ian P. Newton, Meirong Zhao, Weiping Liu. Dichlorodiphenyldichloroethylene exposure reduces r-GCS via the suppressed Nrf2 pathway in HepG2 cells. Environmental Toxicology. 2016, 31(3), 350-9.

17. Xiaoting Jin, Bin Xue, Qunfang Zhou, Ruijun Su, Zhuoyu Li*. Mitochondrial damage-mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure. The Journal of Toxicological Sciences. 2018, 43 (2), 101-111.

18. Xiaoting Jin, Li Song, Xiangyuan Liu, Hangqing Li, Long Cheng, Zhuoyu Li*. Protective effects of vitamins C and E on dichlorodiphenyltrichloroethane-induced genotoxicity and hepatotoxicity in human liver cells. Molecular & Cellular Toxicology. 2017, 13 (2), 155-164.

19. Xiaoting Jin, Meilan Chen, Ruijin Li, Quan An, Li Song, Yi Zhao, Hong Xiao, Long Cheng*, and Zhuoyu Li*. Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure. Archives of Toxicology. 2016, 90 (8), 1929-38.

20. Ruijun Su#, Xiaoting Jin#, Hanqing Li, Leiru Huang, Zhuoyu Li*. The mechanisms of PM2.5 and its main components penetrate into HUVEC cells and effects on cell organelles. Chemosphere. 2019, 241 (2020) 125127.

21. Liang Lyu#, Xiaoting Jin#, Zhuoyu Li*, Sha Liu, Yi Li, Ruijun Su, Huilan Su. TBBPA regulates calcium-mediated lysosomal exocytosis and thereby promotes invasion and migration in hepatocellular carcinoma. Ecotoxicology and Environmental Safety 192 (2020) 110255.

22. Ruijun Su#, Xiaoting Jin#, Weifang Zhang, Zhuoyu Li*, Xiaona Liu, Jie Ren. Particulate matter exposure induces the autophagy of macrophages via oxidative stress-mediated PI3K/AKT/mTOR pathway. Chemosphere. 2017, 167, 444-53.

23. Xiaona Liu#, Xiaoting Jin#, Ruijun Su, Zhuoyu Li*. The reproductive toxicology of male SD rats after PM2.5 exposure mediated by the stimulation of endoplasmic reticulum stress. Chemosphere. 2017, 189, 547-55.

24. Ruijun Su#, Xiaoting Jin#, Liang Lyu, Junsheng Tian, Sajid Amin, Zhuoyu Li*. The potential immunotoxicity of fine particulate matter based on SD rat spleen. Environmental Science and Pollution Research (Environ Sci Pollut Res Int). 2019, 26 (23), 23958-66.

三、主持承担科研和人才项目情况

1. 国家自然科学基金委重大研究计划的重点支持方向，92043202，肺造血免疫介导的室内细颗粒物致心血管系统危害特征的研究，2021/01-2022/12，300万元，子课题负责人（80万）。

2. 国家自然科学基金面上项目，21976114，大气细颗粒物影响肺部血小板生成的理化因素及机制，2020/01-2023/12，65.00万元，项目负责人。

3. 山东省组织部，泰山学者青年专家人才计划，2020.01-2024.12，50.00万元，项目负责人。

4. 国家自然科学基金青年项目，21707085，环境PM2.5通过PPARɑ介导的心肌能量代谢重构诱导心力衰竭的毒性机制，2018/01-2020/12，26.00万元，项目负责人。

5. 山西省青年基金项目，201701D221244，TBBPA通过影响巨噬细胞极化介导子宫内膜癌恶化的分子毒理研究，2017/07-2019/12，3.00万元，项目负责人。

6. 中国博士后基金一等资助，2017M610120，环境PM2.5暴露引起大鼠心力衰竭的毒性效应及机制研究，2017/06-2019/12, 8.00万元，项目负责人。

四、联系方式

邮箱：xtjin@qdu.edu.cn

办公地点：青岛大学浩园医学综合楼A座405-1室