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郑玉新,bat365官网登录入口院长,博士,首席教授,博士生导师。国家杰出青年基金获得者,山东省泰山学者特聘教授。
现任国家自然科学基金委医学科学部专家咨询委员会委员、国家环境与健康咨询委员会委员、中国毒理学会监事长、中国环境诱变剂学会生物标志物专业委员会主任委员。在IPCS/WHO危险度评价咨询委员会、WHO纳米健康工作组等国际组织任咨询专家。目前担任《中华预防医学杂志》副主编以及《科学通报》等多个国内学术期刊编委,担任TAAP和BES两个国际期刊的编委。
曾任中国疾病预防控制中心职业卫生与中毒控制所副所长、WHO职业卫生合作中心(北京)主任、国家职业卫生标准委员会副主任委员、中国毒理学会副理事长、中国毒理学会工业毒理专业委员会主任委员、中华预防医学会卫生毒理学专业委员会主任委员等。
研究方向为环境有害因素对健康影响的标志物及其转化应用。曾主持完成的科研项目主要包括国家自然科学基金重点项目和面上项目、973项目、国家“十一.五、”、“十二.五”科技支撑项目、卫生公益性行业科研专项重点项目以及国际合作项目等。
获中华预防医学奖、“十一.五”国家科技计划执行突出贡献奖等奖项。主编和参编书籍6部,发表论文300余篇。培养博士和硕士研究生40余名。
一、目前执行的科研项目
1. 国家自然科学基金重大研究计划集成项目“大气细颗粒物健康危害的系统毒理学与系统流行病学研究 ”(91943301) 2020.1-2022.12 主要参加者
2.国家自然科学基金重大研究计划重点支持项目“交通尾气颗粒物致健康损害效应的关键组分及人群生物标志物研究 ”(91643203)2017.1-2020.12 项目负责人
3.科技部重点研发计划“基于人群队列的食品污染物生物标志物研究与应用”(2017YFC1600202) 2018.01-2021.12,项目负责人
二、近两年发表的论文
1.Zhang, Z.; Su, H.; Ahmed, R. Z.; Zheng, Y.; Jin, X., Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism. Environ Pollut 2020, 264, 114659.
2.Zhang, J.; Zhou, Q.; Su, R.; Sun, Z.; Zhang, W.; Jin, X.; Zheng, Y., Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure. The Science of the total environment 2020, 721, 137792.
3.Wang, X.; Zhao, Y.; Luo, J.; Xu, L.; Li, X.; Jin, Y.; Li, C.; Feng, M.; Wang, Y.; Chen, J.; Hou, Y.; Zhao, Q.; Zhao, J.; Ning, B.; Zheng, Y.; Yu, D., MicroRNA hsa-miR-1301-3p Regulates Human ADH6, ALDH5A1 and ALDH8A1 in the Ethanol-Acetaldehyde-Acetate Metabolic Pathway. Molecular pharmacology 2020, 98 (2), 120-129.
4.Wang, T.; Wang, H.; Chen, J.; Wang, J.; Ren, D.; Hu, W.; Wang, H.; Han, W.; Leng, S.; Zhang, R.; Zheng, Y., Association between air pollution and lung development in schoolchildren in China. Journal of epidemiology and community health 2020.
5.Li, Y.; Yang, M.; Meng, T.; Niu, Y.; Dai, Y.; Zhang, L.; Zheng, X.; Jalava, P.; Dong, G.; Gao, W.; Zheng, Y., Oxidative stress induced by ultrafine carbon black particles can elicit apoptosis in vivo and vitro. The Science of the total environment2020, 709, 135802.
6.Li, D.; Chen, S.; Li, Q.; Chen, L.; Zhang, H.; Li, H.; Yu, D.; Zhang, R.; Niu, Y.; Lu, S.; Ye, L.; Zeng, X.; Dong, G.; Chen, R.; Aschner, M.; Zheng, Y.; Chen, W., Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure. Part Fibre Toxicol 2020, 17 (1), 22.
7.Jiang, Q.; Zhang, C.; Chen, S.; Shi, L.; Li, D. C.; Lv, N.; Cui, L.; Chen, Y.; Zheng, Y., Particulate Matter 2.5 Induced Developmental Cardiotoxicity in Chicken Embryo and Hatchling. Frontiers in pharmacology 2020, 11, 841.
8.Jiang, Q.; Xu, X.; Zhang, C.; Luo, J.; Lv, N.; Shi, L.; Ji, A.; Gao, M.; Chen, F.; Cui, L.; Zheng, Y., In ovo very early-in-life exposure to diesel exhaust induced cardiopulmonary toxicity in a hatchling chick model. Environ Pollut 2020, 264, 114718.
9.Jiang, M.; Li, D.; Piao, J.; Li, J.; Sun, H.; Chen, L.; Chen, S.; Pi, J.; Zhang, R.; Chen, R.; Leng, S.; Chen, W.; Zheng, Y., Real-ambient exposure to air pollution exaggerates excessive growth of adipose tissue modulated by Nrf2 signal. The Science of the total environment 2020, 730, 138652.
10.Dai, Y.; Zhou, W.; Jia, Q.; Dong, H.; Niu, Y.; He, J.; Bin, P.; Yi, J.; Xiang, Y.; Duan, H.; Huang, H.; Sha, Y.; Shen, M.; Ye, M.; Huang, X.; Zheng, Y., Utility evaluation of HLA-B*13:01 screening in preventing trichloroethylene-induced hypersensitivity syndrome in a prospective cohort study. Occup Environ Med 2020, 77 (3), 201-206.
11.Cui, L.; Shi, L.; Li, D.; Li, X.; Su, X.; Chen, L.; Jiang, Q.; Jiang, M.; Luo, J.; Ji, A.; Chen, C.; Wang, J.; Tang, J.; Pi, J.; Chen, R.; Chen, W.; Zhang, R.; Zheng, Y., Real-Ambient Particulate Matter Exposure-Induced Cardiotoxicity in C57/B6 Mice. Frontiers in pharmacology 2020, 11, 199.
12.Cheng, W.; Liu, Y.; Tang, J.; Duan, H.; Wei, X.; Zhang, X.; Yu, S.; Campen, M. J.; Han, W.; Rothman, N.; Belinsky, S. A.; Lan, Q.; Zheng, Y.; Leng, S., Carbon content in airway macrophages and genomic instability in Chinese carbon black packers. Arch Toxicol 2020, 94 (3), 761-771.
13.Chen, S.; Li, D.; Wu, X.; Chen, L.; Zhang, B.; Tan, Y.; Yu, D.; Niu, Y.; Duan, H.; Li, Q.; Chen, R.; Aschner, M.; Zheng, Y.; Chen, W., Application of cell-based biological bioassays for health risk assessment of PM2.5 exposure in three megacities, China. Environ Int 2020, 139, 105703.
14.Zheng, X.; Wang, G.; Bin, P.; Meng, T.; Niu, Y.; Yang, M.; Zhang, L.; Duan, H.; Yu, T.; Dai, Y.; Zheng, Y., Time-course effects of antioxidants and phase II enzymes on diesel exhaust particles-induced oxidative damage in the mouse lung. Toxicol Appl Pharmacol 2019, 366, 25-34.
15.Yang, M.; Li, Y.; Meng, T.; Zhang, L.; Niu, Y.; Dai, Y.; Gao, W.; Bloom, M. S.; Dong, G.; Zheng, Y., Ultrafine CB-induced small airway obstruction in CB-exposed workers and mice. The Science of the total environment 2019, 671, 866-873.
16.Wang, G.; Zheng, X.; Duan, H.; Dai, Y.; Niu, Y.; Gao, J.; Chang, Z.; Song, X.; Leng, S.; Tang, J.; Zheng, Y., High-content analysis of particulate matters-induced oxidative stress and organelle dysfunction in vitro. Toxicology in vitro : an international journal published in association with BIBRA 2019, 59, 263-274.
17.Li, D.; Zhang, R.; Cui, L.; Chu, C.; Zhang, H.; Sun, H.; Luo, J.; Zhou, L.; Chen, L.; Cui, J.; Chen, S.; Mai, B.; Chen, S.; Yu, J.; Cai, Z.; Zhang, J.; Jiang, Y.; Aschner, M.; Chen, R.; Zheng, Y.; Chen, W., Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China. Environ Pollut 2019, 248, 874-887.
18.He, Z.; Zhang, R.; Chen, S.; Chen, L.; Li, H.; Ye, L.; Li, Q.; Wang, Z.; Wang, Q.; Duan, H.; Niu, Y.; Xiao, Y.; Dong, G.; Li, D.; Yu, D.; Zheng, Y.; Xing, X.; Chen, W., FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. Environ Pollut 2019, 252 (Pt A), 607-615.
19.Chu, C.; Zhou, L.; Xie, H.; Pei, Z.; Zhang, M.; Wu, M.; Zhang, S.; Wang, L.; Zhao, C.; Shi, L.; Zhang, N.; Niu, Y.; Zheng, Y.; Zhang, R., Pulmonary toxicities from a 90-day chronic inhalation study with carbon black nanoparticles in rats related to the systemical immune effects. Int J Nanomedicine 2019, 14, 2995-3013.
20.Chu, C.; Zhang, H.; Cui, S.; Han, B.; Zhou, L.; Zhang, N.; Su, X.; Niu, Y.; Chen, W.; Chen, R.; Zhang, R.; Zheng, Y., Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation. J Hazard Mater 2019, 369, 180-190.
21.Chen, Z.; Yang, L.; Huang, Y.; Spencer, P.; Zheng, W.; Zhou, Y.; Jiang, S.; Ye, W.; Zheng, Y.; Qu, W., Carcinogenic risk of N-Nitrosamines in Shanghai Drinking Water: Indications for the Use of Ozone Pretreatment. Environ Sci Technol2019, 53 (12), 7007-7018.
22.Chen, S.; Li, D.; Zhang, H.; Yu, D.; Chen, R.; Zhang, B.; Tan, Y.; Niu, Y.; Duan, H.; Mai, B.; Chen, S.; Yu, J.; Luan, T.; Chen, L.; Xing, X.; Li, Q.; Xiao, Y.; Dong, G.; Niu, Y.; Aschner, M.; Zhang, R.; Zheng, Y.; Chen, W., The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure. Environ Int 2019, 131, 104943.
23.Zheng, J.; Zheng, W.; Zhou, Y.; Jiang, S.; Spencer, P.; Ye, W.; Zheng, Y.; He, G.; Qu, W., Heavy Exposure of Waste Collectors to Polycyclic Aromatic Hydrocarbons in a Poor Rural Area of Middle China. Environ Sci Technol 2018, 52 (15), 8866-8875.
24.Wang, Y.; Duan, H.; Meng, T.; Shen, M.; Ji, Q.; Xing, J.; Wang, Q.; Wang, T.; Niu, Y.; Yu, T.; Liu, Z.; Jia, H.; Zhan, Y.; Chen, W.; Zhang, Z.; Su, W.; Dai, Y.; Zhang, X.; Zheng, Y., Reduced serum club cell protein as a pulmonary damage marker for chronic fine particulate matter exposure in Chinese population. Environ Int 2018, 112, 207-217.
25.Wang, H.; Duan, H.; Meng, T.; Yang, M.; Cui, L.; Bin, P.; Dai, Y.; Niu, Y.; Shen, M.; Zhang, L.; Zheng, Y.; Leng, S., Local and Systemic Inflammation May Mediate Diesel Engine Exhaust-Induced Lung Function Impairment in a Chinese Occupational Cohort. Toxicol Sci 2018, 162 (2), 372-382.
26.Wang, G.; Zheng, X.; Tang, J.; Niu, Y.; Dai, Y.; Duan, H.; Zheng, Y., LIN28B/let-7 axis mediates pulmonary inflammatory response induced by diesel exhaust particle exposure in mice. Toxicol Lett 2018, 299, 1-10.
27.Niu, Y.; Zhang, X.; Meng, T.; Wang, H.; Bin, P.; Shen, M.; Chen, W.; Yu, S.; Leng, S.; Zheng, Y., Exposure characterization and estimation of benchmark dose for cancer biomarkers in an occupational cohort of diesel engine testers. J Expo Sci Environ Epidemiol 2018, 28 (6), 579-588.
28.Dai, Y.; Ren, D.; Bassig, B. A.; Vermeulen, R.; Hu, W.; Niu, Y.; Duan, H.; Ye, M.; Meng, T.; Xu, J.; Bin, P.; Shen, M.; Yang, J.; Fu, W.; Meliefste, K.; Silverman, D.; Rothman, N.; Lan, Q.; Zheng, Y., Occupational exposure to diesel engine exhaust and serum cytokine levels. Environ Mol Mutagen 2018, 59 (2), 144-150.
三、曾经主持的主要科研项目
1.国家自然科学基金应急管理项目(81842037)2019.01-2019.12预防医学学科发展战略研究 课题负责人
2. 职业有害因素检测评估及职业中毒等重要职业病防治研究(2014BAI12B00),国家科技支撑计划课题(12.5),579万,2014.01-2016.12,总项目协调人
3.职业有害因素早期健康效应的检测与评估技术研究(2014BAI12B02),国家科技支撑计划课题(12.5), 2012-2016,课题负责人
4.A collaborative research project between the U.S. National Cancer Institute and the National Institute for Occupational Health and Poison,A cross-sectional pilot molecular epidemiology study of occupational exposure to diesel exhaust and early biomarkers、2012—2020Principal Investigator
5.柴油机尾气致暴露工人血清炎性因子改变以及机制研究,国家自然科学基金委海外及港澳学者合作研究基金项目(81428021) 2015.01- 2016.12 项目负责人
6.职业暴露柴油机尾气致健康损害生物标志物及其机制研究)国家自然科学基金重点项目(81130050)2012-2016 项目负责人
7. 职业卫生检测与健康监护技术研究卫生行业科研专项项目(200902006)2009-2012项目负责人
8.劳动卫生与职业病学 国家杰出青年基金(30625031)2007-2010负责人
9.重金属和有机溶剂对工人健康损害的预防控制研究 国家科技支撑计划课题(11.5)(2006BA106B02)2007-2012项目负责人
10.突发化学中毒事件第一现场处置关键技术研究 卫生公益性行业科研专项重点项目(200802020)2006-2009 项目负责人
11.Korea Science Foundation(E00002)Studies on the toxic responses of fine particles in metropolitan area and prevention by extracts of herbal medicines. 2006-2007 Principal Investigator
12.“ECPs致DNA损伤及其修复与遗传通路的研究” 973项目《环境化学污染物致机体损伤及其防御的基础研究》课题三(2002CB512903)2002-2007 项目负责人
13.三氯乙烯接触性皮炎的发病机制和生物标志物研究 国家自然科学基金(30271115)2003-2005负责人
14.焦炉工肺癌的环境-机体交作用机制研究 国家自然科学基金(39970633)2000-2002 负责人
15.职业性神经毒物易感性的分子遗传学研究 国家自然科学基金(39970640)1998-2000负责人
四、主要科学技术奖励
1. 十一五国家科技计划执行突出贡献奖 ,2011,第1位
2. 中华预防医学二等奖,2009年,第1位
3. 中华预防医学二等奖, 2007年,第1位
4. 国家质量监督检验检疫总局科技兴检奖三等奖,2005年,第1位